Replicating clinical placebo effects in computational trials: Bridging the gap between in silico and clinical studies
Publications

October 18, 2025

Replicating clinical placebo effects in computational trials: Bridging the gap between in silico and clinical studies

This study introduces a novel computational framework that integrates circadian hormonal fluctuations into virtual placebo groups, enhancing the physiological realism of cardiac safety simulations.

ELEM Biotech at the Safety Pharmacology Society Annual Meeting 2025
Events

October 13, 2025

ELEM Biotech at the Safety Pharmacology Society Annual Meeting 2025

ELEM Biotech is participating in the Safety Pharmacology Society (SPS) Annual Meeting, taking place 13–15 October 2025 in Utrecht,

Digital twins and Big AI: the future of truly individualised healthcare
Publications

August 1, 2025

Digital twins and Big AI: the future of truly individualised healthcare

Big AI merges physics-based digital twins and data-driven intelligence to deliver truly personalised medicine.It unites interpretability and speed, enabling accurate, individualised predictions from

Computational fluid dynamics for vascular assessment in hepatobiliopancreatic surgery: a pilot study and future perspectives
Publications

April 1, 2025

Computational fluid dynamics for vascular assessment in hepatobiliopancreatic surgery: a pilot study and future perspectives

The purpose of our study is to describe the feasibility of a computational fluid dynamics model to predict hepatic artery flow and its variations following gastroduodenal (GDA) or common hepatic

A porohyperelastic scheme targeted at High-Performance Computing frameworks for the simulation of the intervertebral disc
Publications

February 18, 2025

A porohyperelastic scheme targeted at High-Performance Computing frameworks for the simulation of the intervertebral disc

The finite element method is widely used for studying the intervertebral disc at the organ level due to its ability to model complex geometries. An indispensable requirement for proper modelling

Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Publications

December 26, 2024

Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators

Accurate assessment of drug-induced proarrhythmic riskusing sex-specific cardiac

Impact of Geometric Simplifications on Cardiac Computational Models of Electrophysiology to Assess Cardiac Resynchronization Therapy interaction models against 4D flow MRI data 
Publications

December 25, 2024

Impact of Geometric Simplifications on Cardiac Computational Models of Electrophysiology to Assess Cardiac Resynchronization Therapy interaction models against 4D flow MRI data 

The objectives of our work are to create computational models of electrophysiology of human cardiac anatomies with a range of detail, reproduce a LBBB population of patients with and without CRT

A pipeline for developing digital cardiac twins integrating cardiovascular magnetic resonance and electrocardiographic imaging: results from the MyoFit46 study 
Publications

October 28, 2024

A pipeline for developing digital cardiac twins integrating cardiovascular magnetic resonance and electrocardiographic imaging: results from the MyoFit46 study 

This study presents a proof-of-principle pipeline to build personalized digital cardiac twins by integrating cardiovascular MRI and electrocardiographic imaging, demonstrating how engineers,

Expanding Digital Twins Use from Biopharma to Virtual Human Development
Media Coverage

October 1, 2024

Expanding Digital Twins Use from Biopharma to Virtual Human Development

ELEM Biotech’s CTO, Mariano Vázquez, was interviewed by GEN – Genetic Engineering & Biotechnology News about the growing role of digital twins in biopharma. He discussed how these models are

Virtual clinical QT exposure-response studies – A translational computational approach
Publications

April 18, 2024

Virtual clinical QT exposure-response studies – A translational computational approach

A recent paradigm shift in proarrhythmic risk assessment suggests that the integration of clinical, non-clinical, and computational evidence can be used to reach a comprehensive understanding of the

Advancing aortic stenosis assessment: validation of fluid-structure interaction models against 4D flow MRI data 
Publications

April 18, 2024

Advancing aortic stenosis assessment: validation of fluid-structure interaction models against 4D flow MRI data 

 This study represents a significant step towards integrating in silico technologies into real clinical contexts, providing a robust framework for improving aortic stenosis diagnosis and the design

Tell-Tale Heart: They show how to simulate its aging with a digital version, to prevent conditions and expedite treatments
Media Coverage

February 28, 2024

Tell-Tale Heart: They show how to simulate its aging with a digital version, to prevent conditions and expedite treatments

A development by the Barcelona Supercomputing Center and ELEM Biotech allows the creation of a digital twin of a heart and the simulation of its function over time, and its reaction to various