May 23, 2026
In this study we investigate how experimental ion channel variability and extreme drug exposure jointly shape the concentration- QT relationship and proarrhythmic risk profile of
April 4, 2026
Our results demonstrate the models’ capacity to accurately replicate flow dynamics. In addition, we illustrate how computational models can serve as valuable cross-checks to reduce noise and
January 13, 2026
By accurately replicating pressure-volume loop characteristics and hemodynamic alterations commonly seen in clinical settings, this model enhances the understanding of HFrEF and may support the
December 8, 2025
AWARDED 2026 SPS PUBLICATION. These findings demonstrate that computational models capture variability in drug response across pathologies and sexes, offering a predictive framework for preclinical
November 1, 2025
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING JOURNAL. This paper presents an innovative approach that couples a 3D electromechanical model of the heart with a 3D fluid mechanics model of
October 18, 2025
Paper of the Year Award 2025 from The Journal of Precision Medicine: Health and Disease - The work addresses the long-standing gap in computational trials of reproducing clinical placebo effects in
August 1, 2025
Digital twins and AI are converging to shape the future of healthcare, a powerful concept now known as Big
April 1, 2025
The purpose of our study is to describe the feasibility of a computational fluid dynamics model to predict hepatic artery flow and its variations following gastroduodenal (GDA) or common hepatic
February 18, 2025
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE JOURNAL. The objective of this study is to present framework, validated both against literature and experiments, aiming to enable intervertebral disc
December 26, 2024
Our results show significant differences between 3D and 0D single-cell models as risk levels increase, underscoring the ability of 3D modeling to capture more complex cardiac
December 25, 2024
The objectives of our work are to create computational models of electrophysiology of human cardiac anatomies with a range of detail, reproduce a LBBB population of patients with and without CRT
October 28, 2024
This study presents a proof-of-principle pipeline to build personalized digital cardiac twins by integrating cardiovascular MRI and electrocardiographic