Impact of endocrine disruptors from mother’s diet on immuno-hormonal orchestration of brain development and introduction of the virtual human twin tool
Publications

March 1, 2023

Impact of endocrine disruptors from mother’s diet on immuno-hormonal orchestration of brain development and introduction of the virtual human twin tool

REPRODUCTIVE TOXICOLOGY JOURNAL. To help to identify the key data gaps, this paper aims to present (a) how transplacental EDs modify immune system and brain development, and (b) how these mechanisms

Ventricular anatomical complexity and sex differences impact predictions from electrophysiological computational models
Publications

February 13, 2023

Ventricular anatomical complexity and sex differences impact predictions from electrophysiological computational models

The aim of this work was to analyze the influence of sex hormones and anatomical details (trabeculations and false tendons) on the electrophysiology of healthy human

Concomitant Respiratory Failure Can Impair Myocardial Oxygenation in Patients with Acute Cardiogenic Shock Supported by VA-ECMO
Publications

April 16, 2022

Concomitant Respiratory Failure Can Impair Myocardial Oxygenation in Patients with Acute Cardiogenic Shock Supported by VA-ECMO

We hypothesized in NSS the heart would be more likely to receive hypoxemic blood than the brain due to the proximity of the coronary arteries to the aortic annulus. To test this, we conducted a

Study protocol: MyoFit46—the cardiac sub-study of the MRC National Survey of Health and Development
Publications

April 14, 2022

Study protocol: MyoFit46—the cardiac sub-study of the MRC National Survey of Health and Development

By combining well curated, prospectively acquired longitudinal data of the NSHD with novel CMR–ECGI data and sharing these results and associated pipelines with the CMR community, MyoFit46 seeks to

Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy
Publications

September 10, 2021

Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy

Using a translational approach in pigs and patients with established myocardial infarction, we tested and validated a novel 3D methodology to assess ventricular scar using custom transmural criteria

HPC compact quasi-Newton algorithm for interface problems
Publications

July 3, 2020

HPC compact quasi-Newton algorithm for interface problems

In this work we present a robust interface coupling algorithm called Compact Interface quasi-Newton (CIQN). It is designed for computationally intensive applications using an MPI multi-code

Implications of bipolar voltage mapping and magnetic resonance imaging resolution in biventricular scar characterization after myocardial infarction
Publications

January 17, 2019

Implications of bipolar voltage mapping and magnetic resonance imaging resolution in biventricular scar characterization after myocardial infarction

We aimed to study the differences in biventricular scar characterization using bipolar voltage mapping compared with state-of-the-art in vivo delayed gadolinium-enhanced cardiac magnetic resonance

Fully coupled fluid-electro-mechanical model of the human heart for supercomputers
Publications

December 9, 2018

Fully coupled fluid-electro-mechanical model of the human heart for supercomputers

In this work, we present a fully coupled fluid-electro-mechanical model of a 50th percentile human heart. The model is implemented on Alya, the BSC multi-physics parallel code, capable of running

Complex Congenital Heart Disease Associated With Disordered Myocardial Architecture in a Midtrimester Human Fetus
Publications

October 20, 2018

Complex Congenital Heart Disease Associated With Disordered Myocardial Architecture in a Midtrimester Human Fetus

The aim of this study is to describe, for the first time, in 3 dimensions and nondestructively the detailed remodeling of cardiac microstructure present in a human fetal heart with complex

Evaluating the roles of detailed endocardial structures on right ventricular haemodynamics by means of CFD simulations
Publications

September 13, 2018

Evaluating the roles of detailed endocardial structures on right ventricular haemodynamics by means of CFD simulations

The aim of this study is to characterise RV haemodynamics including detailed endocardial structures like trabeculae, moderator band, and papillary

Left Ventricular Trabeculations Decrease the Wall Shear Stress and Increase the Intra-Ventricular Pressure Drop in CFD Simulations
Publications

April 11, 2018

Left Ventricular Trabeculations Decrease the Wall Shear Stress and Increase the Intra-Ventricular Pressure Drop in CFD Simulations

The aim of the present study is to characterize the hemodynamics of left ventricular (LV) geometries to examine the impact of trabeculae and papillary muscles (PMs) on blood flow using high